There was some antagonism on behalf of the Indians and on occasion the would relapse back to their pagan gods ,but for the majority it was not a problem. The Jesuits became their main providers giving clothes and sustenance. .
Three Jesuits and Irishman, a Catalan, and a Portuguese man arrived in 1588 from Brazil. They promptly moved from Asuncion to proselytize among the Indians along the upper Rio Paran.(1) With the exploration of Guiara and the first settlement called Loreto, the Jesuits influence was spreading. Indians flocked to this remote reduction and seemed to be quite content there. Not far from Loreto the Jesuits founded San Ignacio only four miles farther up the Parnapanema. In 1598 Philip the third ascended to the throne. He proclaimed a doctrine that was called the "sword of the word" and it should be used to subjugate the Paraguayan Indians, and make them into happy subjects. Two Italian Jesuits were the main men responsible for the great growth of the reductions. They made it all the way to Sao Paulo in 1620. In Sao Paulo, they came across an enigmatic Jesuit named Ruiz de Montoya he soon became to supreme leader to all the Jesuits. Montoya entered in the Jesuits in 1572 is was a man of humility and integrity. He was dedicated to his faith and missionary work. Moreover, he believed his work in South America was of biblical importance. So the string of reductions ran from Loreta all the way. The Jesuits had began a system that would last more than a century . The reductions is on of history's greatest experiments in communal living, the Jesuits had soon organized about one hundred thousand Guarnai in about 20 reductions and they dreamed of a Jesuit empire that would stretch from the Paraguay-Paran-confluence to the coast and back to the Paran headwaters. But, the power and influence would soon turn into tribulations for the Jesuits. .
In 1629 trouble was brooding in Sao Paulo.