We can then use the difference for suspected presymptomatic cases and in prenatal testing. (Murray,1982).
Limb girdle is a clinically and genetically heterogeneous group of conditions. Limb girdle is caused by a muscle specific protease deficiency. Less then 10 % of cases are inherited through autosomal dominant trait and are mostly mild. One sub type may be allelic to autosomal Emery- Dreifuss dystrophy. All other cases are inherited as autosomal recessive traits affecting both male and female. ( Azofeifa, 1995), (Matthews, 1996), (Perloff, 1967).
Distal myopathies are associated with wasting and weakness of the distal muscle, usually without the noticeable involvement of other muscle groups. Most people with this are only mildly affected although some may ultimately develop serious problem with walking and everyday life. (Padberg, 1997).
Oculopharyngeal (Bareau's disease) is an autosomal dominant disorder that has been largely described as occurring in French Canadians descending from a couple who immigrated in 1634. The onset of this disease is late in adulthood of progressive ptosis and dysphagia, which is followed by involvement of other cranial and limb muscle. This gene is located on the 14th chromosome. This disease is likely to be genetically homogeneous but with different ancestral mutations in different populations. ( Bakker, 1997), ( Essen, 1997).
Molecular biological techniques have made the prevention of most forms of dystrophy possible through genetic counseling and prenatal testing. There also have been some major advances in the management of the disease. No matter what type of disease or what stage the disease is in certain things you should consider. Eat a well balanced diet with plenty of fibre to help with constipation, especially when a person becomes immobile. You need to be on the look out for excessive weight gain. Never let a person stay in bed for a long period of time because it can accelerate weakening of the muscles.
