Furthermore, cord blood stem cells are easier for the donor to accept, and do not exert a strong immune reaction as is found with adult bone marrow stem cells.
Stem cells were first used medically over a century ago, when physicians treated patients with anemia and leukemia with the consumption of bone marrow (Nation Marrow Donor Program). Although these initial treatments were unsuccessful, bone marrow transplants began in the 1950's which could successfully cure certain forms of leukemia. The transplantation of bone marrow is essentially stem cell transplantation, because bone marrow would lack the potential to cure degenerative diseases if not for its high concentration of stem cells. .
During this time period, it was discovered that the body had the ability to recognize which cells were foreign, allowing the immune system to prevent infection from invading bacteria. The immune system identifies cells by monitoring HLA's, a structure that exists on the perimeter of all cells, and differs between each person (NMDP). Although this system of cellular identification is usually beneficial because it protects the body, it served as a major hindrance for bone marrow transplantation, because donor cells must be the perfect match or else they will be rejected by the host's immune system. In 1968, the first successful stem cell transplant occurred between two twins "thus assuring that the operation would be successful (NMDP). It was not until the early eighties that a national registry of individuals' HLA types was created, providing a nationwide system for bone marrow transplantation.
The first stem cell transplant using cord blood (blood taken from the umbilical cord) on a human occurred in 1988. A young boy in Salisbury, North Carolina suffered from Fanconi anemia, a rare degenerative disease that results in death within the first 10 years of life. This boy is alive today. (McDonald) In the past 15 years, stem cell transplants have been made on thousands of individuals in the United States, successfully treating patients suffering from a wide variety of rare genetic disorders.