live animal market in Guangdong, China. There has been Evidence of virus infection .
detected in other animals such as a raccoon-dog, cats, and in humans working at the same .
market. People who have pets that are infected with the virus is definitely gurantee .
contaminated. Precaution such as wearing gloves and a face mask is being done by .
citizens living with in that infected area. According to Science Magazine , all the animal .
isolates retain a 29 nucleotide sequence, which is not found in most human isolates. .
According to CDC , the characterization of the genome of SARS-CoV is 29,727.
nucleotides in length and has11 open reading frames, and its genome organization is .
similar to that of other coronaviruses. The analyses and sequence comparisons showed.
that SARS-CoV is not closely related to any of the previously characterized .
coronaviruses. .
The detection of SCoV like viruses in small wild mammals in live retail market.
indicates a direct link of interspecies transmission, although the natural reservoir is not.
known. It's known that people with in that area are eating or consuming the animals by.
purchasing them at a retail market. Afterwards , the spreading of the coronavirs from.
animal to human is now human to human. Researchers and a joint team of experts has .
agreed on recommendations for monitoring the live animal trade and searching for a.
SARS reservoir. Epidemiologists estimate that a single infectious case of SARS will infect.
about three secondary cases in a population that has not yet established control measures.
Public-health efforts to reduce spreading of the virus are expected to have a impact on.
reducing the size of the epidemic. .
"The viral main proteinase (Mpro, also called 3CLpro), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal structures for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro.
