Poliovirus is protected from detergents, organic solvents, and acidic conditions by its capsid. .
It is important to understand the genome of the poliovirus to help with research in biomedicine. The mRNA genome of the poliovirus weighs approximately 2,600 kD and takes up 23% of the total weight of the particle. The capsid encloses a positive RNA strand of roughly 7500 nucleotides. The poliovirus weighs 8300kDa, and the mRNA genome part of the virus weighs approximately 2,600 kDa, which is 23% of the total weight of the particle. Because of its RNA, the poliovirus has a high mutation rate, which is advantageous because it allows rapid replication and adaptation to a new environment. All the serotypes of the poliovirus have a 3" end with polyadenylic acid and the 5" end linked to a virus-encoded protein with 22 amino acids called VPg. Genome replication can occur because it contains a cis-acting signal in the first 88 nucleotides. A site that regulates translation called the internal ribosomal entry site (IRES) follows this region. This site is separated from a long open reading frame of the only polypeptide it encodes, the polyprotein, by a 154nt. The polyprotein is 247 kDa and it is highly unstable. The polyprotein undergoes many proteolytic cleavages to make functional structural (VP1-VP4) and nonstructural proteins, which is characteristic of viruses that have positive RNA strands. Following the ORF, there is a 3" non-translated region that forms a double stem-loop structure. Genome replication and virion reproduction takes place in the infected host. .
Poliovirus has three distinct serotypes: P1, P2, and P3 (Virology Book). These serotypes are classified based on how well they are able to make monoclonal antibodies to inactivate the viral infectivity (virology). Within these serotypes, the strains vary in their pathogenicity. These different strains of the poliovirus are highly homologous in their nucleotides and their amino acid sequences, but have different morbidity rates.
Polio follows infection with any one of three related enteroviruses: poliovirus types 1, 2, or 3. ... Transmission: Poliovirus is spread through person-to-person, fecal-oral contact. ... There is also evidence that flies can passively transfer poliovirus from faeces to food. ...
Poliomyelitis, better known as polio or infantile paralysis, is the infectious viral disease that sometimes results in paralysis. Polio was a big cause of death of children and many elderly adults in the 20th century. Over 100,000 people have been affected with polio since the 20th century, and a ne...
The discovery that infectious diseases thrived because of our lack of knowledge in the mechanics of them, which gave way to the growing interest and need in controlling such infectious diseases. The complete eradication of any current problematic disease is virtually impossible because of the many...
Are Humans Really an Endangered Species? The Yanomami tribe is located in the Amazon Basin. The Yanomami civilization has said to of have lasted before Christ. In the Amazon Basin there are many endangered species, one of these endangered species are human. Since 1950, the tribe has decreased i...
How the Polio Vaccine Caused More Harm Than Good Poliomyelitis, also called polio or "infantile paralysis," is an acute viral infection caused by the poliovirus. In the past, because of the many cases and critical results from epidemics of polio, people feared the disease since it had left many pa...
At six weeks, an inactivated poliovirus, DTaP, Haemophilus influenza type b (HIB), Pneumococcal conjugate, and Rotavirus are given with little time intervals in between. Again at six, ten and fourteen weeks old infants are injected again with the inactivated poliovirus, DTaP, HIB, Pneumococcal conjugate, and Rotavirus. ...
Poliomyelitis is defined as "an acute infectious disease caused by the poliovirus and characterized by fever, motor paralysis, and atrophy of skeletal muscles often with permanent disability and deformity and marked by inflammation of nerve cells in the anterior gray matter in each lateral half of the spinal cord -- called also infantile paralysis" (Merriam-Webster). ...
Poliomyelitis, also called polio or "infantile paralysis," is an acute viral infection caused by the poliovirus (Schulelein ##-##). In the past, because of the many cases and critical results from epidemics of polio, people feared the disease since it had left many patients paralyzed for life, and ...
Considerable evidence demonstrates that animal experimentation is inefficient, unreliable and unsafe. It is also unnecessary because newly developed methodologies are more valid and less expensive than animal studies. An increasing number of doctors and scientists agree that the methodology of today...
