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Gene Therapy for Alzheimer's Disease

            
             In Conventional medicine with the advancements in technology, Gene therapy has become an upwelling in therapeutics and has introduced promising prospects for the prevention and cure of incurable or difficult to cure diseases. With the advent of concern for the growing cases of dementia globally, it has become important to constitute therapeutic methods for Alzheimer's disease (AD). Although much research is still being done in this avenue, gene therapy appears to be opportune. Here we look at some of the research done to approach the Diseases from a genetic standpoint. We have analyzed five different research articles with the aim of understanding this disease at the Genomic level.
             Initially analysis was done on the Duplication of amyloid precursor protein and it was found to be the cause of early onset dementia. It focused on diagnostic techniques and comparative results. A second research was analyzed based on the use of the Nerve Growth Factor to treat cholinergic neuron loss in AD Patients and this was found to not cure the disease but rather slow down the process. Another research presented here investigates the Acat1 Knockdown gene therapy that decreases amyloid – beta plaques. Being obliquely related to the first article, it showed a promising therapeutic index for AD. The forth journal was a characterization of AD based on the build-up of beta-amyloid peptides, hyper-phosphorylated 'tau' and synapse dysfunction in the brain with minor emphasis on the Crtc1 gene. In Our final chapter we analyzed a journal based on WNT 7A signaling and how it promotes dendritic spinal growth and synaptic strength. By fulfilling our aims in this research document, we have been able to present the known information of Alzheimer's disease and analyse some of current possible routes and prospects being investigated with Gene therapy today.
             Introduction.
             Gene therapy for Alzheimer's disease- possible routes and prospects.


Essays Related to Gene Therapy for Alzheimer's Disease

1. human genome project

Scientists are taking medical technology to new heights as they race to map all of the genes, nearly 100,000, in the 23 chromosomes of the human body .Along the way, they hope to understand the basis of, and maybe even create different methods of treating certain genetic diseases, like Alzheimer's and Muscular Dystrophy. ... Once a person gets the gene, it is only a matter of time before they get the disease. ... Gene -Therapy has greatly benefited gene mapping. ... There is also a direct relation to the sequence of genes and producing effective drugs to work on diseases that have many di...

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2. The Importance of Medicine

Histone modification results in the activation or suppression of transcription of the gene. ... Epigenetic have been associated with the chronic degenerative diseases such as Alzheimer's and Parkinson's diseases (Landgrave-Gómez, Mercado-Gómez and Guevara-Guzmán, 2015, p. 4). Epigenetic and Alzheimer's Disease (AD) AD is a degenerative disease that affects the brain. ... However, therapies based on epigenetic has shown better potency in its treatment. ... Regarding this, therapy based on antioxidants and nutrition have proved to increase the dormancy of PD in patients...

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3. Molecular Basis of the Neurodegenerative Disorders

Over the past decade, many genes underlying heritable forms of the neurodegenerative disorders have been identified, including Alzheimer's disease, Parkinson's disease, Huntington's Disease and Friedreich's ataxia. ... Autosomal dominant traits also are considered in diseases such as Alzheimer's disease and Parkinson's disease. ... Alzheimer's disease is a form of dementia that occurs in elderly people. ... Two major types of changes occur in the brains of people with Alzheimer's disease. ... Studies done on understanding the pathogenesis of Alzheimer...

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4. Genetic Testing And Its Social Implications

This feature can be a disease causing mutation or a marker DNA sequence used to detect presence of another gene. ... Testing for serious late-onset disease before the symptoms occur. Testing to assess the probability of developing complex disease. ... Meiotic recombinations that always occur take place during gamete generation, may separate a disease-associated gene and a marker DNA sequence which is used to detect mutated genes. ... Although the frequency of the defective gene will not change, at least homozygous recessive mutation carrying individuals are not produced. ...

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5. Genetic Testing and Engineerin

This feature can be a disease causing mutation or a marker DNA sequence used to detect presence of another gene. ... Testing for serious late-onset disease before the symptoms occur. Testing to assess the probability of developing complex disease. ... Meiotic recombinations that always occur take place during gamete generation, may separate a disease-associated gene and a marker DNA sequence which is used to detect mutated genes. ... Although the frequency of the defective gene will not change, at least homozygous recessive mutation carrying individuals are not produced. ...

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6. Neurodevelopment and Neurocognitive Disorders

Likewise behavioral therapy in conjunction with medications can improve children behavior as well. ... Some of the neurocognitive disorders are Alzheimer's, Parkinson's, HIV Infection, Lewy body disease and vascular diseases. ... Moreover gene mutation can cause disease directly, but these mutations only affect a small percentage of the individuals. ... This gene is often found in juvenile Parkinson's disease. ... This gene found in late stages of Parkinson disease. ...

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7. Cloning

For example, a team of researchers has successfully altered the genes of a tomato so it will grow entirely in salt water. ... Cloning technology can help "perfect" gene therapy, the actual correction or replacement of defective gene sequences. ... The resulting child and its descendants would carry a corrected gene in every cell. Cloning technology may be able to cure cystic fibrosis, muscular dystrophy, and Huntington's disease. ... Damage done by degenerative disorders like diabetes, Parkinson's disease or Alzheimer's disease might be reversed. ...

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8. genetic enhancement

Saving Lives, Changing Genes How far would you go in order to save a loved one from dying from, what is now, a treatable disease? ... Genetic enhancement should be legal in all states in order to ensure enhancement of genes to aid in the prevention of diseases. ... Genetic enhancement would strictly be gene mutilation in order to promote disease prevention (Schmitt 111). ... He will not contract Alzheimer's like the five generations of men before him" (Schmitt 111). ... Both viral and nonviral vector systems have great promise in gene therapy. ...

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9. Cigarette Smoking and the Body

Premature coronary heart disease could lead to sudden death. ... At least 30% of people suffering with heart disease will end up dying. ... These include Photodynamic Therapy, Immunotherapy, Gene therapy, Cytokines, Interferons, Onconase and L-NDDP. Once these treatments are tested to be effective and safe, a person suffering from lung cancer can be less dubious about being treated and hence the deaths caused by lung cancer would decrease. [6] A smoker may still want to argue that fewer smokers get Alzheimer's and Parkinson's diseases than non-smokers. ... Smoking gives you bad brea...

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