Genotyping and its Application to Disease Identification and Treatment.
In the last few years two groups, a private consortium and a public one, have been rushing to sequence the human genome and build the "book of life-. The Human Genome Project would provide a catalogue and map documenting each base pair in the human genome. It is envisioned that with this blueprint of humanity, researchers and drug companies would be able to make news discoveries at a much greater pace and could possibly revolutionize several areas of research.
Article one talks about the initial project to sequence the human genome run by the public consortium whose largest contributor was the Whitehead Institute for Genome Research at MIT. It discussed how the research would help drug companies create new drugs and would expose the genetic causes of diseases.
Article two discussed how the genome sequencing of other animals could aid the analysis of the human genome. Since the human genome is extremely similar to the mouse genome, comparison between the two is leading to unexpected discoveries. For instance, by comparing the differences between the two genomes, scientists can identify functionally important regions of the human genome because they are differentiate us and make us human. Scientists can also look at genes that are the same and then perform experiments based on those genes on mice rather than humans because they contain the same information.
Article three discusses the importance of the human genome sequencing in identifying what cause "complex disorders-. These are disorders that are influenced by several genes as well as the environment. Such diseases would include diabetes, obesity, and cancer. When the interplay of so many factors are involved it is hard to apply simple Medelian rules of inheritance as one can with simple disorders such as Huntington's disease or cystic fibrosis. Thus scientists turn to a genome wide view among many individuals.
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