Then they will act as if they do not care anymore, then the uncaring attitude increases until they no longer care about much at all. Depression also comes after a teenager is trying to learn about him or herself and understand their body, and their emotions towards others. Sometimes these emotions have to deal with homosexuality and finding out whether or not they like people of the same gender. To many people the idea of homosexuality is disgusting and most people know how others feel about it, so when someone who thinks that he or she is gay, they feel out of place, especially if their family, friends, and loved ones are homophobic. Another cause of depression may be the Acne drug, Accutane. There was a study on this drug. Researchers have tested Accutane on one person and this person used it for a few months, then after a while signs of depression began to appear. When the drug had stopped being used by the person, the signs of the depression cleared. Another cause of depression is said to be smoking, and that most depressed teenager's who are in fact depressed have been smoking. "Teens who smoked were at an increases risk of depression at a 73% higher rate than other teens." Sometimes teens may be depressed and it will be easy for people to notice, this is not always the case. In every teen's life, at some point, they are on a roller coaster ride, for this reason it is hard for anyone, even the parents, to distinguish depression from just a plain bad day. This is why it is important for parents to know what to look for, otherwise something bad may happen. One sign to watch for is their grades in school, if you have to, go around and meet with the teachers to see how they are doing in classes and how they are acting when you are not around. As some teens get depressed they sometimes begin not to care for their grades and may not try too hard to keep up in classes. Teens also may begin to isolate themselves from friends and family and only hang around in their room by themselves or try and try to get moments for them.