Frances Eliza Hodgson was born on November 24, 1849, in Manchester, England, the third of Edwin Hodgson's and Eliza Boond's five children. Her father ran a prosperous firm, which specialized in the trade of decorative arts for the interiors of houses. At the time, Manchester was experiencing a textile boom, which infused the town with a rising middle-class, and because these families were erecting magnificent houses, Hodgson's merchandise was in demand. The prosperity of the Hodgson family was cut short in 1854 when Edwin suffered a stroke. Even more devastating to the family fortune was the American Civil War, which caused a cessation of cotton shipments from Southern plantations, crippling Manchester's economy. Eliza Hodgson decided to emigrate to America, and in 1865, when Burnett was sixteen, the family settled in a small town about twenty-five miles from Knoxville, Tennessee. This move would prove instrumental in Burnett's development as a writer. Although she had always been obsessed with storytelling and often amused her schoolmates by acting out tales of adventure and romance, the financial strain of the emigration caused her to turn to writing as a means of supplementing the family's income. The move from industrial England to rural America was for the family a journey to the green, natural world that would become a central theme in many of Burnett's later works, including The Secret Garden. .
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Burnett's first published story, "Miss Caruthers's Engagement,"" appeared in a magazine called Godley's Lady's Book in 1868. After the death of her mother in 1872, the family became increasingly dependent on her writing income. She accelerated her career as a popular writer and sold stories to many magazines. In September of 1873 she married Swann Burnett, a doctor from Tennessee who was preparing to specialize in the treatment of the eye and ear. He wished to further his specialty by studying in Europe, and Burnett financed his wish, once again becoming responsible for the bulk of her family's income.