In this novel there are several factors that led to the death of Santiago Nasar. These several factors are shown through character actions, dialoged and characteristics. There"re also techniques and events that show the factors involved with Santiago's death. .
One of these factors is fate. In this novel there are several events that suggest that Santiago was fated to die on this day. One of these even that suggest this is how Placida Linero didn't " notice any ominous augury- in Santiago's dream. This significance of this is that Placida " had a well-earned reputation as an accurate interpreter of other people's dreams-, this suggest that Santiago was fated to die as his own mother and clairvoyant could not predict the death.
Another example of fate is that everyone who was about to tell Santiago about his upcoming murder had been suddenly distracted by the Bishop. One example of a person getting distracted before telling Santiago about his death how Father Carmen Amador forgets to tell Santiago at the arrival of the bishop.
A third example of this fate is when Santiago's mother locked the door. This event suggest a bit of irony as Santiago's mother actually locked the door, thinking Santiago was in the house, to protect him but in effect actually was one of the factor involved in his death.
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A minor factor that coincides with the Placida locking the door is dislike. The dislike of Santiago from Divina Flor who lied to Placida saying Santiago was in the house effectively caused Placida to close the door thus locking Santiago out. So the fact the Divina Flor didn't like Santiago also caused him to die.
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Another factor the contributed to Santiago's death is his own naivety and ignorance. One example of Santiago's ignorance in the morning where he didn't " recognize the omen-. The fact that Garcia-Marquez refers to the omens suggest a certain significant of omens and superstition and if so partially implies that Santiago has some reverence to these omens.