There have been many researches and tests done on the genetic causes of Sickle Cell Anemia and how it develops, as well as its effects on the circulatory, muscular, and respiratory systems, and it's effects on the joints and other systems of the body. Most of the research has been done, to explore on the reasons why Sickle Cell Anemia mostly effects the African-American community and people who are from the West Coast of Africa. It has also been known that Sickle Cell Anemia also effects people from the Mediterranean countries. .
Sickle Cell Anemia is the most common single gene disorder found mostly among Black Americans. According to scientific research, it usually affects approximately one in 375 people of African roots. Sickle Cell conditions are also found in people from the Mediterranean countries such as Turkey, the Arabian peninsula, and the Indian subcontinent. Extensive research has also proved that Spanish speaking people in the United States, and people from the Caribbean and South and Central America, are also affected by Sickle Cell Anemia. The first case of Sickle Cell Anemia was first published in 1910 by scientists, and has been followed by at least six decades of many observations, which include genetic, molecular, and pathologic observations. A whole ton of data has been found on Sickle Cell Anemia of children since the 1970's. The United States has studied 3,500 patients with the Sickle Cell disease, and based on these studies, the longevity and quality of life of these patients have greatly improved. It has been researched and proven that Sickle Cell Anemia have come from mutations within the human genes that are associated with being immune to malaria, a parasitic blood disease which is carried and contracted by infected mosquitoes. Since malaria is mostly found in hot, moist areas in West Africa and the Mediterranean, people originating from that area produced an immunity towards malaria, but with consequences.