Peroxisomes are small organelles with a single-membrane involved in many metabolic interactions such as oxidation of fatty acids (Cooper, 2000). They are synthesized on free ribosomes and imported into peroxisomes as completed polypeptide chains. Peroxisomes replicate by fission and do not contain their own DNA. The main task of the peroxisome is to oxidize fatty acid chains into acetyl co-enzyme A, a major source of metabolic energy. In this process, hydrogen peroxide is created as a bi-product. However, the peroxisome contains a substantial amount of the enzyme, catalase, which is able to decompose hydrogen peroxide into water and oxygen. In addition, the hydrogen peroxide can be used to oxidize other substances such as phenols, formic acid, and formaldehyde, thus ridding the cell of the toxin. Peroxisomes have slightly altered functions in different areas of the body. In liver cells for example, they are involved in the synthesis of bile acids, while in animal cells, they aid in the synthesis of dolichol and cholesterol. Another extremely important function of the peroxisome is the biosynthesis of a phospholipid called plasmalogen. The ester bond to glycerol is replaced with an ether bond. This lipid is essential for membrane components in brain, heart, and lung tissue (Cooper, 2000).
Zellweger's Syndrome.
Though the peroxisome is a small organelle, defects in it are extremely serious and can cause a host of physiological problems. Zellweger's Syndrome is an autosomal recessive disorder part of a family of diseases called peroxisome biogenesis disorders (NINDS, 2012). Biogenesis disorders are caused by mutations in PEX (peroxisomal biogenesis factor) genes 1, 2, 3, 5, 6, 10, 12, 13, 14, 16, 19, and/or 26. These genes encode peroxins, which are proteins essential in the formation and further development of peroxisomes. Defects in PEX genes lead to tissues and cells accumulating long-chain and branched-chain fatty acids that are normally degraded within the peroxisome, as previously described.
DOWN SYNDROME Down Syndrome is a very serious disease. ... He noticed that the children with Down Syndrome looked the same. ... Down said they looked like natives from Mongolia. ... People with Down Syndrome could mate a have children. ... If a person with Down Syndrome would mate, Down Syndrome could be passed to the offspring. ...
Doctors look for signs such as heart defects, any narrowing of the intestines at a certain point, or if the white blood count of chromosomes is off. The original name for Down syndrome, or Down's syndrome was/is "Mongolism," because people that are affected by this syndrome tend to look like Mongolians or people with facial abnormalities. Until 1959, the cause of Down syndrome was unknown. ... People that have Down syndrome usually have symptoms indicating that there is something wrong with them, such as looking like a Mongolian. ... The facial features are very small, and may be close ...
Nelson syndrome displays a wide range of symptoms. ... Another symptom of Nelson syndrome is headaches. ... Patients suffering from Nelson syndrome also face visual disturbances. ... A thyroid examination is done to look for enlargements due to autoimmune hypothyroidism, hyperthyroidism, and hyper pigmentation (Chrousos, 25 Jul 2003). An abdominal test is done to look for liver disturbances (Chrousos, 25 Jul 2003). ...
Society has looked at them as a monster causing many problems. ... Down syndrome was looked as a crime and seemed as it was not right. ... Those with the disability have been looked down on. ... Disability people are looked down. ... People really need to take a look and understand that having Down syndrome is nothing bad. ...
Ada learns to farm and defend herself from chickens with the help of smart-mouthed Ruby Thewes, played by Renee Zellweger, who manages to add a few moments of comic relief to this otherwise dreary film. ... Zellweger steals the show as far as the secondary roles go though. ...
Down Syndrome Down Syndrome is the most common genetic disorder. Down syndrome affects people of all ages, races, and economic levels. ... Women with Down syndrome can and do have children. ... Men with Down syndrome are believed to be sterile. ... The research provides ways to look at many important problems, such as, heart disease, Alzheimer's disease and Leukemia. ...
DOWN SYNDROME Down syndrome is a chromosomal anomaly which usually causes delays in physical and intellectual development. ... The exact cause and prevention of Down syndrome is unknown. ... There are three major types of Down syndrome. ... Children with Down syndrome look more like their families then they do one another. ... Children with Down syndrome are no different. ...
One of the most common of these genetic disorders is Down syndrome. ... Down syndrome occurs when there is an abnormality in chromosome 21. ... WHAT IS DOWN SYNDROME? There are three main types of Down syndrome. ... By looking at the karyotype researchers can identify Down syndrome prenatally. ...
Down Syndrome Have you ever been in a situation where you were confronted by a child who has Down Syndrome and were unsure of how to act around that child? ... These Page proteins cause the typical features of Down Syndrome. ... Children with Down Syndrome have distinct physical characteristics. ... There are three common types of Down Syndrome, the most common one being trisomy 21, which is found in about 95% of people with Down Syndrome. ... Most people might look at the individual infected and tell themselves how lucky they are , not to have to go through what most of the...