Many of Rembrandt's works are of Saskia. Rembrandt and Saskia moved to Amsterdam and bought a house in Nieuw Doelenstraat. Unfortunately, Rembrandt faced financial difficulties as well that he never paid attention but would later affect him. After Saskia gave birth to four children, only the last one, Titus, survived to grow up. Many believe that the birth of Titus explained Saskia's fatal illness. On June 14, 1642, Saskia van Ulenborch died when Titus was only a year old. Five days later, she was buried in the Oude Kerk. In the 1640s, Rembrandt van Rijn hired Hendrickje Stoffels as his servant that later became his mistress after the death of Saskia. Yet, he could not marry Hendrickje or else he would have lost the income from Saskia's part of the estate. Hendrickje played "Saskia's role in all but name" (White 129). Hendrickje and Titus became models in numerous works of Rembrandt. Rembrandt and his new partner soon had a girl named Cornelia. .
In 1653, Rembrandt began to face trouble, the worst year of the economic depression caused by the First Anglo-Dutch War. The war almost led to a financial collapse in Amsterdam. Rembrandt owed money for his house, paid no interest on the exorbitant amount for the past five years, and had let the original owner pay the taxes on the house for the past three years. Rembrandt van Rijn sold many of his possessions to pay off his debt. He finally left his house and moved into a simpler one on the other side of the city, Jordaan. .
In July of 1663, Hendrickje Stoffels died. Many say that the plague could have possibly killed her. Her burial took place in the Westerkerk. Titus then administered and looked after his father's affairs along with supporting his father financially. In February, 1668, Titus married Magdalena van Loo, the daughter of the silversmith, Jan van Loo. The newly-weds went to live on the Singel, where Magdalena's mother lived; this left Rembrandt alone with his fourteen-year-old daughter, Cornelia.