Furthermore, according to research, The World Health Organization Global Burden of Disease Survey estimates that by the year 2020, major depression will be second to ischemic heart disease in the amount of disability experienced by sufferers. MDD can transform or distort the way you see yourself, life, also those around you. With major depressive disorder, you often tend to see everything in a negative prospective. Secondly, it is difficult for the person to imagine that a problem or situation can be solved in any positive way. In addition, this disorder is generally encountered in primary practice, although more in frequently under-diagnosed. Only 42% of patients with major depressive disorder were diagnosed properly by their primary physician, according to, The World Health Organization in General Health Care.
Biological factors that affect and/or influence major depressive disorder, such as, genetics play a major role in causing depression. Based on MDD, studies have been continued extensively, studies say, the brain function is the influence of neurotransmitters and the hormones. The human body's brain is known to be called the "command center". This controls all the basic functions of our movements, our bodies, as well as our emotions and feelings. Therefore, depression is looked at several aspects in the brain function, such as, the limbic system, this area is responsible for emotions, physical, sexual drives, along with stress response. The hypothalamus, amygdala, and the hippocampus are structures within the limbic system that are associated with the emotional reaction. Hormones and the endocrine system is another area from research in influential the causes of clinical depression. .
Furthermore, cortisol is a hormone in our blood and it is secreted by the adrenal glands. It is believed, this hormone may be related to clinical depression since the very high levels typically decrease to a normal state once the depression disappears.