1. Free Radical and Mitochondrial Dysfunction
Introduction Oxygen is damaging to aerobic organisms at levels higher than are found in the atmosphere. ... However, oxidative damage affects replication and transcription of mitochondrial DNA (mtDNA) and results in a reduction of mt function, which renders more ROS and further damage to mtDNA (Cui et al., 2011). ... Another type of molecule that is highly susceptible to ROS diminishing effects is DNA. The reaction of an oxygen radical with DNA can result in loss of bases, or cause a strand breakage, with a likelihood of a harmful or deadly outcome (Klaunig et al., 2010). What is more, the del...
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- Approx Pages: 5
- Has Bibliography
- Grade Level: Undergraduate