1. Human molecular diseases
Unequal crossing over during meiosis can lead to duplications of genetic material; this can have a large impact if the reading frame is disrupted. ... If, as a result of the point mutation or partial deletion, the reading frame is shifted, the consequence is that entirely different codons, specifying different amino acids are produced after the mutation. ... This proposed that the Duchenne form of the disease involved the disruption of the reading frame, and therefore there is a complete absence of the dystrophin in the patient. ...
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- Grade Level: High School