1. A Look at Zellweger's Syndrome
Zellweger's Syndrome Though the peroxisome is a small organelle, defects in it are extremely serious and can cause a host of physiological problems. ... Yik et al (2009) tabulated deleterious alleles for PEX1, including twelve new deleterious mutations (seven frameshift, one nonsense, and four splice junction), in addition to eight previously reported deleterious mutations (three frameshift, two nonsense, one in-frame duplication, one in-frame deletion, and one splice junction) that resulted in shortened and non-functional PEX1 proteins. ...
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- Grade Level: Undergraduate