Native Americans were threatened by lots of disease, and especially one type of disease called smallpox, which as Brown describes, "broke out in this country and is sweeping all before it"(Brown), and "may wiped the Mandan and Rickaree Tribes of Indian clean from the face of the earth without surprise" (Brown). ... Peter's up the Missouri River from St. Louis"(Brown), which most of Historians agree with. ... It carried smallpox inside and appeared "among the southern-most tribes along the river" (Brown) before it actually speared out to the "Mandans...

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• Grade Level: High School