Risk is an eternal predicament, and the edge for bordering high risk could be set at a lower or higher cut-off point. ... IRBs tackle the challenge of deciding if a given level of cancer risk is sufficient in value to enroll healthy subjects in trials designed to lower that risk (Hampton 1). ... Separate from the difficulties of classifying what quantity of risk is sufficient to be branded as high risk, determining risk level is elaborate, because it is not always clear which of many risk factors should be fused into a risk estimate (Bernhard 1). There could be limited epidemiological proof ab...

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