Introduction The £]-Globin Gene is one of two genes that make up a multigene family. Members of a multigene family not only share DNA-sequence homology, but also have gene products that are functionally associated (Klug and Cummings, 566). ... The DNA sequence associated with each of the HSs contains numerous binding sites for erythroid-specific and ubiquitous transcription factors (Bulger and Groudine, 1999). ... Globin gene expression along with chromatin structure and timing of replication across the entire locus is significantly affected when the LCR is deleted (Iler et. al, ...

• Word Count: 1387
• Approx Pages: 6
• Grade Level: Undergraduate

Introduction The key to human success has been in our ability to convey our thoughts and ideas through language. ... Also, these four mutations in these genes are the only ones to have been replicated in multiple experiments. ... This mutation has also been replicated in many studies since then (although it has also not been found in other papers). ... Using DNA pooling and genetic fine-mapping, two more genes, both on chromosome 6, were discovered to be linked with DD (DCDC2 and KIAA0319). ...

• Word Count: 2290
• Approx Pages: 9
• Has Bibliography
• Grade Level: Undergraduate