1. Neural Induction
BMP antagonists expressed in the organiser repress the epidermalising activity of BMP-4, and the release from inhibition is sufficient to specify neural fates. ... The amniote node, like the Xenopus organiser expresses BMP antagonists, including follistatin, noggin and chordin (McMahon et al 1998). ... This suggests that the node produces additional neural inducers that are not BMP antagonists. ... In contrast, injecting cells expressing chordin, a BMP antagonist, expands the neural plate at the expense of the epidermis. ... It has been suggested that during neural induction, BMP antagonis...
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- Approx Pages: 5
- Grade Level: Undergraduate