Each of these groups accompanied by at least one example and within the autosomal recessive disorders, haemoglobinopathies are discussed. There is then a brief discussion about the molecular basis of some cancers and the other groups of human molecular diseases. ... The field is however developing quickly with ever growing knowledge of gene structure and functions, from projects such as the Human Genome project. ... A missense mutation involves the substitution of a different base which results in a different amino acid being encoded. ... In the Becker form the reading remains inta...

• Word Count: 3615
• Approx Pages: 14
• Grade Level: High School

While heme is the prosthetic group that can reversibly bind to oxygen, globin is the protein that encloses and safeguards the heme molecule. ... Each member of the group are either turned "on" or "off" during different stages of development. ... The only difference between these two genes products is a single amino acid. ... The £]-globin locus also contains a single pseudogene, £r £]1, within the group. ... All five functional genes of the beta-globin locus encodes products that are 146 amino acids long and contain two correspondingly sized introns at exactly the same ...

• Word Count: 1387
• Approx Pages: 6
• Grade Level: Undergraduate

The Cavendish team, (having been embarrassed in April 1951 by Pauling beating them to the discovery of the structure of keratin), were determined not to let it happen again (A Twist of Fate, The Chain of Events). It was the following May that Watson attended Wilkins" lecture on X-ray crystallography that led him to believe the secret was in the structure of DNA (The Chain of Events). ... As Watson and Crick continued their work, Linus Pauling gave the team a scare later in December 1952 when he wrote a letter to his son stating that he would soon publish an article containing the structure o...

• Word Count: 2807
• Approx Pages: 11