One of the first insights from comparative genomics was unexpected, namely, that the majority of human genes have a single identifiable ortholog in other vertebrate species (3, 4). ... CCCTC-binding factor (CTCF) is an almost ubiquitously expressed DNA-binding protein that can divide transcriptional domains and appears to be involved in the three-dimensional organization of the genome (11, 12). There have been somewhat conflicting reports suggesting that the binding events of CTCF are considerably more conserved between mammals, whereas (at the same time) they appear to have evolved in the mou...

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